Table 5.

Bivariate relationship of eGFR and proteinuria and 25-yr ESRD in men in MRFITa

GFR (ml/min per 1.73 m2)Protein in Urine from Labstix
Negative/Trace1+2+ or Higher
<60
    ESRD (n [%])457 (3.94)17 (5.88)22 (40.91)
    HR (95% CI)a2.36 (1.38 to 4.01)3.07 (0.41 to 22.99)32.87 (15.20 to 71.10)
60 to 75
    ESRD (n [%])3984 (1.28)105 (5.71)34 (17.65)
    HR (95% CI)a0.84 (0.59 to 1.21)2.80 (1.18 to 6.61)12.93 (5.52 to 30.26)
≥75
    ESRD (n [%])7939 (1.31)213 (3.29)83 (13.25)
    HR (95% CI)a1.00 (reference)1.92 (0.82 to 4.51)11.42 (5.99 to 21.77)
  • a From Cox regression model including indicator variables for categories of GFR and proteinuria and covariates listed in footnote b of Table 4.