Table 6.

Sensitivity and specificity of SICK in the detection of analgesic-associated ESRDa

SICKOther PatientsTotalSensitivity/Specificity (%)
All patients (15 SICK, 204 other ESRD)
    all analgesicsb
        ≥1 kg before index year42125Sensitivity = 16
        otherc11183194Specificity = 94
        ≥0.3 kg/yr before index yr51419Sensitivity = 26
        otherc10190200Specificity = 95
    Phenacetin
        ≥1 kg before index year202Sensitivity = 100
        otherc13204217Specificity = 94
All patients except phenacetin users (12 SICK, 203 other ESRD)
    analgesics other than phenacetin
        ≥1 kg before index year12021Sensitivity = 5
        otherc11183194Specificity = 94
        ≥0.3 kg/yr before index yr21416Sensitivity = 13
        otherc10189200Specificity = 95
  • a Assumption: Patients must have taken the specified dose before the index year to be considered analgesic associated. Numbers in bold type are used in calculating sensitivity and specificity.

  • b Dose is the combined dose of all analgesic components, including aspirin, salicylamide, acetaminophen, and phenacetin.

  • c Including lower total doses before the index year, use after the index year only, and no use.