Table 3.

Renal insufficiency in sickle cell anemiaa

Age (yr; median [range])AER (mg/g creatinine)CrCl (ml/min)BMI (kg/m2)SBP (mmHg)DBP (mmHg)Weight (kg)Hb (g/dl)Reticulocytes (%)LDH (U/L)
SS disease
    CrCl > 9030 (19 to 59)220 ± 36137 ± 322.1 ± 0.4124 ± 164 ± 164 ± 18.5 ± 0.113 ± 1509 ± 19
    CrCl < 9037b (22 to 65)626 ± 32b56 ± 8b21.9 ± 0.7125 ± 167 ± 155 ± 1b7.3 ± 0.3b12 ± 4521 ± 8
Other sickling hemoglobinopathies
    CrCl > 9035 (19 to 61)97 ± 22130 ± 330.1 ± 0.8129 ± 175 ± 177 ± 111.6 ± 0.24 ± 1291 ± 12
    CrCl < 9054c (22 to 68)222 ± 106c64 ± 4c26.7 ± 1.3c136 ± 6c76 ± 467 ± 3c10.5 ± 0.4c4 ± 1276 ± 22
  • a AER, albumin excretion rate.

  • b P < 0.05 versus SS disease with CrCl >90 ml/min.

  • c P < 0.05 versus other sickling hemoglobinopathies with CrCl >90 ml/min.