Table 4.

HR and OR for incident CVD by haplotypes in each block from Cox proportional hazards models and logistic regression models in Haplo.glm, respectivelya

HaplotypeHR (95% CI)OR (95% CI)
Model 1Model 2Model 1Model 2
Block A
    A-11.001.001.001.00
    A-20.86 (0.54 to 1.35)0.78 (0.48 to 1.25)1.16 (0.76 to 1.79)1.07 (0.69 to 1.67)
    A-30.80 (0.52 to 1.23)0.70 (0.51 to 0.94)b0.60 (0.39 to 0.92)b0.53 (0.34 to 0.83)c
    A-other1.26 (0.61 to 2.61)1.06 (0.50 to 2.27)1.86 (0.72 to 4.84)1.68 (0.62 to 4.59)
Block C
    C-11.001.001.001.00
    C-20.89 (0.53 to 1.51)0.91 (0.64 to 1.30)0.67 (0.47 to 0.98)b0.64 (0.43 to 0.94)b
    C-32.06 (1.28 to 3.32)c2.12 (1.25 to 3.57)c2.16 (1.20 to 3.91)c1.96 (1.05 to 3.66)b
    C-40.80 (0.54 to 1.20)0.75 (0.48 to 1.16)0.63 (0.34 to 1.16)0.62 (0.33 to 1.18)
    C-other1.89 (1.17 to 3.07)1.59 (0.89 to 2.86)1.69 (0.50 to 5.71)1.62 (0.46 to 5.66)
  • a Model 1 was adjusted for all haplotypes; age; gender; smoking; baseline dialysis modality; BMI; SBP; comorbidity score; diabetes, baseline CVD, and congestive heart failure; and serum albumin, total cholesterol, HDL cholesterol. Model 2 was adjusted for model 1 plus IL-6 and CRP. For Cox regression models, haplotypes from both blocks were included; for logistic regression models, haplotypes from one block were included. CI, confidence interval; HR, hazard ratio; OR, odds ratio.

  • b P < 0.05.

  • c P < 0.01.