Table 4.

Changes in physical performance, physical activity, and quality of life from baseline to 12 wka

VariablePlaceboNDEXND+EXPb
NDEX
Physical performance
    gait speed (cm/s)
        baseline99.8 ± 31.595.1 ± 41.2100.9 ± 35.5105.0 ± 30.3
        3 mo105.7 ± 31.1102.8 ± 38.0103.5 ± 34.2111.2 ± 32.0
        change6.0 ± 17.27.7 ± 16.62.7 ± 17.36.2 ± 18.80.540.71
    stairs (s)
        baseline11.9 ± 10.510.9 ± 6.59.6 ± 4.98.7 ± 4.1
        3 mo11.5 ± 9.79.7 ± 5.710.0 ± 6.28.5 ± 4.9
        change−0.5 ± 4.2−1.2 ± 2.10.4 ± 3.4−0.1 ± 2.10.340.36
    sit to stand (s)
        baseline15.2 ± 3.817.2 ± 10.918.0 ± 11.414.8 ± 4.8
        3 mo15.1 ± 5.115.1 ± 5.915.1 ± 7.412.8 ± 5.6
        change−0.1 ± 3.8−2.1 ± 6.7−2.9 ± 6.8−2.0 ± 3.00.380.30
Physical activity
    accelerometry (arbitrary units)
        baseline41,270 ± 28,04951,471 ± 17,42050,141 ± 34,65247,040 ± 19,323
        3 mo74,864 ± 43,25135,370 ± 61,66464,366 ± 44,88157,703 ± 18,064
        change33,594 ± 34,28333,899 ± 60,28814,225 ± 14,88110,663 ± 18,5150.460.16
    HAP MAS
        baseline66.2 ± 10.161.3 ± 18.667.3 ± 15.762.3 ± 20.1
        3 mo66.2 ± 12.856.0 ± 23.465.3 ± 16.665.2 ± 16.0
        change0 ± 11.3−5.3 ± 11.3−2.0 ± 9.92.9 ± 10.40.660.21
    HAP AAS
        baseline53.4 ± 14.148.0 ± 24.451.9 ± 20.851.6 ± 22.6
        3 mo50.9 ± 18.744.0 ± 25.851.9 ± 20.051.7 ± 20.0
        change−2.5 ± 14.1−4.0 ± 5.70.1 ± 12.90.1 ± 9.30.700.21
Quality of life
    SF-36 Physical Functioning
        baseline60.3 ± 21.855.4 ± 34.750.0 ± 24.749.7 ± 26.9
        3 mo54.4 ± 24.358.9 ± 29.761.5 ± 30.856.3 ± 30.6
        change−5.9 ± 24.33.6 ± 10.111.5 ± 15.46.6 ± 10.80.630.03
    fatigue
        baseline8.1 ± 5.59.7 ± 5.411.0 ± 5.69.1 ± 6.6
        3 mo7.2 ± 4.010.8 ± 4.87.8 ± 4.26.2 ± 5.4
        change−0.9 ± 7.11.1 ± 3.3−3.2 ± 5.4−2.9 ± 4.30.400.06
    anger
        baseline6.1 ± 6.98.2 ± 4.06.5 ± 8.07.3 ± 8.7
        3 mo4.0 ± 3.713.4 ± 8.58.7 ± 7.97.5 ± 9.7
        change−2.1 ± 5.35.2 ± 5.52.2 ± 6.60.2 ± 1.90.06c0.79c
  • a HAP, Human Activity Profile; MAS, Maximum Activity Score; AAS, Adjusted Activity Score.

  • b Analysis was by repeated-measures ANOVA. P values are for each intervention (i.e., the interaction between time and the intervention) and include data from all groups. P values for interactions between the interventions (three-way interactions) are not reported but are >0.10 in all cases except as noted for anger.

  • c Significant interaction present between nandrolone and exercise (P = 0.003). Interaction between nandrolone and exercise was NS for all other outcomes.\