Table 1.

Biological data of rats

ParameterNormal(n = 6)Uremia(n = 6)Uremia + Smad7(n = 6)Nonuremic on PD (n = 8)Uremic on PD(n = 6)Uremic on PD + Smad7 (n = 7)Uremic on PD + Vector (n = 8)
Body weight (g)
    baseline224.7 ± 3.0222.2 ± 2.7224.2 ± 2.8225.9 ± 3.0227.7 ± 2.3219.3 ± 2.2219.7 ± 2.1
    2 wk367.7 ± 10.4332.0 ± 10.1a328.0 ± 9.1a350.9 ± 6.4312.7 ± 5.0b301.8 ± 6.8b301.4 ± 5.6b
    4 wk445.6 ± 18.7401.0 ± 11.6a402.5 ± 10.1a431.1 ± 8.8390.4 ± 5.4a374.3 ± 7.0a372.9 ± 6.7a
    6 wk514.4 ± 17.6442.8 ± 16.3a439.2 ± 14.4a494.7 ± 9.3435.6 ± 9.0b426.1 ± 9.4b423.7 ± 6.8b
Urine volume (ml/24 h)
    baseline11.6 ± 1.111.3 ± 0.711.5 ± 0.611.2 ± 1.112.3 ± 1.111.0 ± 0.311.2 ± 0.9
    2 wk15.3 ± 0.934.4 ± 2.8b34.0 ± 2.7b15.2 ± 1.232.8 ± 1.0b31.1 ± 1.8b34.0 ± 1.7b
    4 wk20.0 ± 1.542.5 ± 2.6b41.8 ± 2.4b19.0 ± 2.143.4 ± 1.4b36.9 ± 2.2b39.1 ± 1.7b
    6 wk20.7 ± 1.547.8 ± 3.2b46.9 ± 3.0b19.1 ± 2.547.1 ± 3.5b41.9 ± 2.245.2 ± 3.3b
  • a P < 0.01,

  • b P < 0.05 versus normal controls.