Table 2.

Biochemical parameters of rats

ParameterNormalUremiaUremia + Smad7Nonuremic on PDUremic on PDUremic on PD + Smad7Uremic on PD + Vector
Serum BUN (mg/dl)
    baseline16.0 ± 0.317.4 ± 0.816.2 ± 0.815.6 ± 0.715.9 ± 0.318.4 ± 1.817.8 ± 0.6
    2 wk16.3 ± 0.535.1 ± 3.4a34.7 ± 3.2a14.6 ± 1.031.5 ± 2.1b37.3 ± 3.1b34.6 ± 2.7a
    4 wk18.1 ± 0.342.0 ± 2.0c40.5 ± 1.9c16.1 ± 1.440.4 ± 4.1b39.9 ± 3.2b38.1 ± 1.4c
    6 wk18.7 ± 1.246.6 ± 2.9c45.8 ± 2.7c16.8 ± 0.950.3 ± 3.3c46.8 ± 2.9b47.0 ± 2.7c
Serum creatinine(mg/dl)
    baseline0.72 ± 0.070.73 ± 0.050.76 ± 0.070.75 ± 0.060.79 ± 0.050.75 ± 0.050.71 ± 0.08
    2 wk0.73 ± 0.091.02 ± 0.11b1.04 ± 0.12b0.74 ± 0.070.96 ± 0.11b1.11 ± 0.08a1.13 ± 0.06a
    4 wk0.75 ± 0.031.04 ± 0.07a1.05 ± 0.06a0.76 ± 0.061.17 ± 0.05c1.29 ± 0.11c1.35 ± 0.09c
    6 wk1.11 ± 0.101.81 ± 0.14a1.78 ± 0.13a1.06 ± 0.091.79 ± 0.09a1.75 ± 0.08c1.76 ± 0.07c
Urine total protein (mg/24 h)
    baseline3.15 ± 0.573.37 ± 0.203.28 ± 0.223.40 ± 0.393.00 ± 0.423.47 ± 0.613.28 ± 0.46
    2 wk21.0 ± 2.129.8 ± 6.129.9 ± 6.220.6 ± 3.428.8 ± 6.126.1 ± 5.525.2 ± 3.9
    4 wk24.7 ± 1.455.1 ± 9.4a54.2 ± 9.2a23.4 ± 3.560.5 ± 4.4a59.2 ± 11.8b53.3 ± 6.6b
    6 wk23.7 ± 1.2137.5 ± 24.5a136.0 ± 23.3a25.0 ± 3.5150.7 ± 20.3c130.6 ± 12.2c132.4 ± 14.8c
Urine albumin (mg/24 h)
    baseline0.044 ± 0.0050.045 ± 0.0050.043 ± 0.0080.050 ± 0.0140.047 ± 0.0050.041 ± 0.0040.040 ± 0.011
    2 wk0.107 ± 0.0402.125 ± 0.415a2.109 ± 0.422a0.112 ± 0.0331.764 ± 0.035c1.710 ± 0.268a2.065 ± 0.098a
    4 wk0.137 ± 0.03110.62 ± 2.404b10.44 ± 2.312b0.098 ± 0.02013.26 ± 1.97b12.13 ± 3.07b13.71 ± 2.77b
    6 wk0.173 ± 0.05330.34 ± 4.36a31.02 ± 4.28a0.123 ± 0.02729.14 ± 8.43b24.81 ± 6.28b29.16 ± 7.95b
  • a P < 0.01,

  • b P < 0.001,

  • c P < 0.05 versus normal controls.