Table 1.

Biochemical parameters groupa

ParameterGroup 1Wild TypeGroup 2LDLR−/−Group 3LDLR−/−Group 4LDLR−/−Group 5LDLR−/−Group 6LDLR−/−Group 7LDLR−/−Group 8LDLR−/−Group 9LDLR−/−
DietChowChowFatFatFatChowFatFatFat
SurgeryShamShamShamShamShamCKDCKDCKDCKD
TreatmentSevelamer 1%Sevelamer 3%Sevelamer1%Sevelamer 3%
N455655757
Presurgical weight (g)22.9 ± 0.723 ± 0.923.5 ± 0.622 ± 0.822 ± 0.524 ± 0.721 ± 1.022 ± 0.820 ± 0.6
Weight at death (g)26 ± 1.731 ± 1.933 ± 1.729 ± 2.028 ± 2.025 ± 0.921 ± 0.826 ± 1.626 ± 1.0
Glucose (mg/dl)183 ± 15272 ± 58b364 ± 57c354 ± 21b465 ± 68c216 ± 69309 ± 19b495 ± 21c290 ± 55b
PTH (pg/ml)19 ± 2025 ± 1223 ± 13NDND174 ± 100b444 ± 98cND10 ± 3
  • a CKD, chronic kidney disease; LDLR−/−, LDL receptor deficient; ND, not determined; PTH, parathyroid hormone.

  • b P < 0.05 versus wild-type chow fed.

  • c P < 0.01 versus wild type chow fed.