Table 2.

Genotype frequencies and OR for SNP showing significant associations with FSGS in AA or EA

SNPHIV StatusGroupn (Frequency)TotalDominant ModelRecessive Model
OR (95% CI)POR (95% CI)P
African Americans
    SNP3A/AA/GG/G
    rs6657893HIV+FSGS35 (0.660)16 (0.302)2 (0.038)530.46 (0.25 to 0.85)0.0150.69 (0.15 to 3.16)1.0
Control114 (0.471)115 (0.475)13 (0.054)242
HIV−FSGS104 (0.547)68 (0.358)18 (0.095)1900.75 (0.53 to 1.06)0.110.89 (0.50 to 1.60)0.77
Control186 (0.474)165 (0.421)41 (0.105)392
CombinedFSGS139 (0.572)84 (0.346)20 (0.082)2430.67 (0.50 to 0.90)0.010.96 (0.56 to 1.65)1.00
Control300 (0.473)280 (0.442)54 (0.085)634
    SNP7T/TT/GG/G
    rs2274626HIV+FSGS21 (0.404)20 (0.385)11 (0.211)520.62 (0.34 to 1.15)0.141.28 (0.61 to 2.70)0.55
Control72 (0.296)129 (0.531)42 (0.173)243
HIV−FSGS53 (0.276)90 (0.469)49 (0.255)1921.08 (0.74 to 1.59)0.701.44 (0.95 to 2.17)0.08
Control114 (0.292)201 (0.515)75 (0.192)390
CombinedFSGS74 (0.303)110 (0.451)60 (0.246)2440.96 (0.70 to 1.32)0.801.44 (1.01 to 2.05)0.05
Control186 (0.294)330 (0.521)117 (0.185)633
    SNP8G/GG/AA/A
    rs2274625HIV+FSGS51 (0.962)2 (0.038)0 (0.000)532.69 (0.61 to 11.78)0.27
Control218 (0.905)23 (0.095)0 (0.000)241
HIV−FSGS175 (0.911)17 (0.088)0 (0.000)1921.09 (0.59 to 2.02)0.75Zero cell0.55
Control360 (0.918)29 (0.074)3 (0.077)392
CombinedFSGS226 (0.922)19 (0.077)0 (0.000)2450.88 (0.51 to 1.52)0.79Zero cell0.56
Control578 (0.913)52 (0.082)3 (0.047)633
    SNP11C/CC/TT/T
    rs2274623HIV+FSGS50 (0.943)3 (0.056)0 (0.000)530.54 (0.16 to 1.86)0.44
Control216 (0.900)24 (0.100)0 (0.000)240
HIV−FSGS176 (0.917)16 (0.083)0 (0.000)1920.98 (0.53 to 1.83)1.00Zero cell0.55
Control357 (0.915)30 (0.777)3 (0.077)390
CombinedFSGS226 (0.922)19 (0.077)0 (0.000)2450.84 (0.49 to 1.45)0.59Zero cell0.56
Control573 (0.909)54 (0.086)3 (0.048630
    SNP12T/TT/CC/C
    rs2274622HIV+FSGS33 (0.623)18 (0.340)2 (0.038)532.04 (1.08 to 3.82)0.041.87 (0.35 to 9.93)0.61
Control188 (0.770)51 (0.209)5 (0.020)244
HIV−FSGS155 (0.803)36 (0.186)2 (0.010)1930.83 (0.54 to 1.27)0.401.00 (0.18 to 5.55)1.0
Control300 (0.771)85 (0.218)4 (0.010)389
CombinedFSGS188 (0.764)54 (0.219)4 (0.016)2461.05 (0.75 to 1.49)0.791.15 (0.35 to 3.76)0.76
Control448 (0.771)136 (0.215)9 (0.014)633
European Americans
    SNP3A/AA/GG/G
    rs6657893HIV−FSGS68 (0.535)46 (0.362)13 (0.102)1271.09 (0.71 to 1.66)0.751.31 (0.64 to 2.69)0.45
Control153 (0.556)100 (0.364)22 (0.080)275
    SNP7G/GG/TT/T
    rs2274626HIV−FSGS61 (0.473)55 (0.426)13 (0.101)1290.87 (0.57 to 1.32)0.520.67 (0.34 to 1.29)0.27
Control122 (0.439)116 (0.417)40 (0.144)278
    SNP86G/GG/AA/A
    rs2274625HIV−FSGS84 (0.656)32 (0.250)12 (0.094)1281.12 (0.72 to 1.74)0.652.49 (1.07 to 5.81)0.04
Control188 (0.681)77 (0.279)11 (0.039)276
    SNP11C/CC/TT/T
    rs2274623HIV−FSGS84 (0.651)33 (0.256)12 (0.093)1291.14 (0.74 to 1.78)0.572.50 (1.07 to 5.82)0.04
Control190 (0.681)78 (0.280)11 (0.039)279
    SNP12T/TT/CC/C
    rs2274622HIV−FSGS80 (0.620)42 (0.326)7 (0.054)1290.65 (0.43 to 1.00)0.050.53 (0.22 to 1.25)0.18
control143 (0.516)107 (0.386)27 (0.097)277