Table 1.

Baseline characteristics of DCI patients in the discontinuation and reduction protocols

Discontinuation (n = 1127)Reduction (n = 1147)USRDS (n = 309,269)P Value
Age, yr (n, %)0.99
    <207 (0.6)6 (0.5)1354 (0.4)
    20 to 44151 (13.4)153 (13.3)44,740 (14.5)
    45 to 64419 (37.8)427 (37.2)123,024 (39.8)
    65 to 74257 (22.8)254 (22.1)71,744 (23.2)
    ≥75293 (26.0)307 (26.8)68,406 (22.1)
    Mean (SD)62.9 ± 15.663.1 ± 15.60.66
Race0.95
    white673 (59.7)683 (59.6)169,127 (54.7)
    African American357 (31.7)361 (31.5)117,151 (37.9)
    other97 (8.7)103 (8.9)22,991 (7.4)
Sex0.42
    female495 (44.0)523 (45.6)141,362 (45.7)
    male631 (56.0)623 (54.4)167,846 (54.3)
Etiology0.99
    diabetes479 (42.5)490 (42.7)132,954 (43.0)
    hypertension265 (23.5)271 (23.6)88,218 (28.5)
    glomerulonephritis179 (15.9)180 (15.7)34,218 (11.1)
    other204 (18.1)206 (18.0)53,879 (17.4)
Dialysis duration27.3 (10.2 to 57.7)29.4 (12.8 to 59.9)0.06
Estimated dry weight (kg)78.0 ± 22.278.9 ± 23.00.44
Kt/V1.63 ± 0.391.65 ± 0.510.37
  • Age is in years, dialysis duration in months and estimated dry weight. GN, glomerular nephropathy; Kt/V,.

    Demographic data for the discontinuation protocol are for individuals present on December 1, 2005, and for the reduction protocol are for individuals present on July 1, 2006. Estimated dry weight and Kt/V are for November 2005 and June 2006 because this corresponds with earliest EPO administration data used in this study. US Renal Data System (USRDS) data is from prevalent hemodialysis patients in 2004.26

    All comparisons are between the discontinuation and reduction protocols. P values were calculated with t tests for means, the Mann-Whitney-Wilcoxon test was used for medians, and the Cochran-Mantel-Haenszel statistic was used for ordinal data.