Table 4.

Change in creatinine clearance over follow-up by covariate subgroup

Parameter Covariate (at DCCT Closeout)Unadjusted ModelAdjusted Modela
Change in Creatinine Clearance (ml/min per 1.73 m2 each yr; 95% CI)PbChange in Creatinine Clearance (ml/min per 1.73 m2 each yr; 95% CI)Pb
All participants−0.34 (−0.55 to −0.13)−0.32 (−0.55 to −0.09)
Age (yr)
    <30−0.28 (−0.68 to 0.12)0.031−0.43 (−0.87 to 0.01)0.123
    30 to 40−0.16 (−0.45 to 0.14)−0.10 (−0.44 to 0.24)
     >40−0.82 (−1.22 to −0.42)−0.65 (−1.07 to −0.23)
Gender
    women−0.48 (−0.77 to −0.19)0.213−0.46 (−0.78 to −0.14)0.278
    men−0.22 (−0.51 to 0.08)−0.21 (−0.53 to 0.11)
Race
    white−0.31 (−0.52 to −0.11)0.287−0.30 (−0.53 to −0.07)0.496
    nonwhite−1.06 (−2.42 to 0.30)−1.75 (−2.26 to 0.63)
Treatment group
    intensive−0.04 (−0.32 to 0.25)0.004−0.11 (−0.43 to 0.21)0.060
    conventional−0.65 (−0.93 to −0.34)−0.55 (−0.87 to −0.22)
Smoking
    active−0.77 (−1.26 to −0.27)0.047−0.77 (−1.34 to −0.20)0.061
    not active−0.22 (−0.43 to 0.01)−0.18 (−0.42 to 0.06)
Waist quartile, women
    1st−0.91 (−1.45 to −0.37)0.305−1.00 (−1.60 to −0.41)0.254
    2nd−0.54 (−1.07 to −0.01)−0.31 (−0.90 to 0.28)
    3rd−0.18 (−0.86 to 0.51)−0.23 (−0.95 to 0.49)
    4th−0.30 (−0.82 to 0.22)−0.30 (−0.89 to 0.29)
Waist quartile, men
    1st−0.06 (−0.64 to 0.52)0.872−0.17 (−0.85 to 0.51)0.984
    2nd−0.19 (−0.80 to 0.44)−0.14 (−0.81 to 0.53)
    3rd−0.42 (−1.03 to 0.20)−0.32 (−1.00 to 0.35)
    4th−0.21 (−0.73 to 0.34)−0.20 (−0.76 to 0.36)
Systolic BP (mmHg)
    <110−0.24 (−0.65 to 0.17)0.983−0.17 (−0.61 to 0.27)0.935
    110 to 130−0.21 (−0.51 to −0.10)−0.25 (−0.58 to 0.09)
    >130−0.19 (−0.54 to 0.17)−0.14 (−0.50 to 0.23)
HbA1c (%)
    <70.01 (−0.45 to 0.48)0.004−0.09 (−0.60 to 0.41)0.054
    7 to 9−0.14 (−0.40 to 0.13)−0.15 (−0.45 to 0.16)
    >9−0.90 (−1.3 to −0.47)−0.77 (−1.2 to −0.32)
AER (mg/24 h)
    <30−0.20 (−0.42 to 0.02)0.004−0.20 (−0.44 to 0.03)0.038
    30 to 300−0.94 (−1.58 to −0.30)−0.79 (−1.50 to −0.08)
    >300−3.04 (−4.9 to −0.78)−2.95 (−5.49 to −0.40)
  • a Generalized estimating equation model adjusted for age, gender, race, duration of diabetes, treatment group, smoking status, waist circumference, systolic BP, diastolic BP (except with systolic BP), HbA1c, logAER, and iothalamate GFR, each measured at DCCT closeout.

  • b Tests hypothesis that change in creatinine clearance differs among subgroups of covariate.