Table 2.

Effects of dDAVP in combination with CsA on the renal abundance of mRNAa

mRNALocationVHVH + dDAVPCsACsA + dDAVP
NKCC2Co100 ± 1179 ± 344 ± 8b48 ± 7b
NKCC2OM100 ± 882 ± 489 ± 895 ± 9
NCCCo100 ± 4102 ± 715 ± 2b14 ± 3b
Na+,K+-ATPAse α1Co100 ± 1485 ± 343 ± 2b59 ± 3b
Na+,K+-ATPAse α1OM100 ± 494 ± 666 ± 4b71 ± 3b
TonEBPCo100 ± 581 ± 693 ± 379 ± 4b
TonEBPOM100 ± 264 ± 3b56 ± 4b51 ± 4b
TonEBPIM100 ± 1072 ± 4b69 ± 7b81 ± 6b
AQP2Co100 ± 14330 ± 27b35 ± 6b276 ± 30b,c
AQP2OM100 ± 8183 ± 14b40 ± 3b136 ± 7b,c
AQP2IM100 ± 10107 ± 1352 ± 9b90 ± 6c
UT-A2OM100 ± 44237 ± 118b43 ± 5b86 ± 38c
UT-A1IM100 ± 18139 ± 2071 ± 17321 ± 54b,c
ARIM100 ± 11210 ± 16b13 ± 5b192 ± 28b,c
  • a Rats were treated with vehicle (VH), vehicle with dDAVP (VH + dDAVP), CsA, and CsA in combination with dDAVP (CsA + dDAVP) as described in Figure 5. RNA was extracted from the kidneys, and RPA was performed as in Table 1. Relative abundance is shown as means ± SEM; n = 6.

  • b P < 0.05 versus VH.

  • c P < 0.05 versus CsA.