Table 2.

Rates and relative risks (95% confidence intervals) of incident PAD events by level of eGFR: The ARIC Study, 1987 to 2002

ParametereGFR ≥90 (ml/min per 1.73 m2)(n = 6825)eGFR 60 to 89 (ml/min per 1.73 m2)(n = 7079)eGFR 15 to 59 (ml/min per 1.73 m2)(n = 376)
No. of PAD cases45351647
Incidence rate per 1000 person-years4.74.98.6
Model 1a1.01.04 (0.91 to 1.18)1.82 (1.34 to 2.47)
Model 2b1.01.07 (0.94 to 1.23)1.56 (1.13 to 2.14)
Model 3c1.01.08 (0.94 to 1.24)1.54 (1.19 to 2.12)
Model 4d1.01.10 (0.96 to 1.26)1.58 (1.14 to 2.17)
  • a Adjusted for age, gender, race, and ARIC field center.

  • b Additionally adjusted for diabetes, LDL and HDL cholesterol, triglycerides, prevalent coronary heart disease, pack-years of cigarette smoking, BMI, physical activity, use of alcohol, and use of cholesterol medication.

  • c Model 2 plus SBP, DBP, and use of antihypertensive medication.

  • d Model 2 plus fibrinogen, factor VII, factor VIII, and white blood cell count.