Table 4.

Cox proportional hazards analysis of factors that predicted death or hospitalization as a result of sudden cardiac death, heart failure, and atherothrombotic diseases (myocardial infarction, stroke, mesenteric ischemia) using sCD154 as binary end pointa

FactorFirst Hospitalization as a Result of Arrhythmia/Sudden Cardiac DeathHeart FailureAtherothrombotic Diseases
PRR95% CIPRR95% CIPRR95% CI
sCD154 (>6.42 ng/ml)0.9611.020.47 to 2.240.8800.930.34 to 2.520.0086.8031.64 to 28.26
CHD0.2461.470.77 to 2.790.6161.280.50 to 3.270.0013.4951.90 to 6.42
TNT (>0.039 μg/L)0.0013.501.84 to 6.660.0492.301.01 to 5.250.5481.2000.66 to 2.17
  • a The total number of fatal and first nonfatal atherothrombotic events (myocardial infarction, stroke, and mesenteric ischemia) was 46, the total number of fatal and first nonfatal arrhythmia-related events (sudden cardiac death and nonfatal arrhythmia) was 39, and the total number of fatal and first nonfatal heart failure events was 24. Beside sCD154, we included the two most important risk factors for all-cause mortality (see Table 2) in these Cox models. We limited the number of covariates to two considering the event rate. Cox regression analysis revealed that plasma sCD154 more than the cutoff is an independent predictor (RR 6.80; 95% CI 1.638 to 28.26; P = 0.008) for the combined end point death or hospitalization as a result of atherothrombotic events.