Table 1.

Influences of exendin-4 on metabolic and physiologic parameters in db/db and db/m micea

Parametersdb Controldb+0.5 Exendin-4db+1.0 Exendin-4dm Controldm+1.0 Exendin-4
Body weight (g)51.4 ± 4.642.7 ± 4.2b44.1 ± 5.5b31.1 ± 5.5c31.3 ± 3.0c
Liver weight (g)2.4 ± 0.32.2 ± 0.32.6 ± 0.51.3 ± 0.11.2 ± 0.1
Peri-epididymal fat weight (g)3.1 ± 0.22.2 ± 0.4d2.0 ± 0.1c0.8 ± 0.2c0.9 ± 0.2c
Food intake (g)7.4 ± 0.98.5 ± 1.87.5 ± 1.74.4 ± 2.1b2.0 ± 1.0d
Water intake (ml)27.5 ± 8.527.8 ± 9.815.3 ± 3.0b5.7 ± 1.7c4.3 ± 1.8c
Mean SBP (mmHg)103 ± 6102 ± 599 ± 697 ± 798 ± 4
Hematocrit (%)39.1 ± 3.238.8 ± 5.842.6 ± 2.432.6 ± 4.9b34.2 ± 3.4
  • a SBP, systolic BP.

  • b P < 0.05,

  • c P < 0.001,

  • d P < 0.01 versus db/db control mice.