Table 3.

Effects of exendin-4 on renal functional and structural parametersa

Parametersdb Controldb+0.5 Exendin-4db+1.0 Exendin-4dm Controldm+1.0 Exendin-4
Kidney/body weight (%)0.62 ± 0.190.54 ± 0.150.64 ± 0.190.69 ± 0.140.64 ± 0.06
BUN (mg/dl)24.8 ± 6.826.0 ± 3.224.0 ± 2.619.1 ± 3.921.4 ± 2.3
Creatinine (mg/dl)0.08 ± 0.030.09 ± 0.010.08 ± 0.020.09 ± 0.010.09 ± 0.01
Urine volume (ml)22.7 ± 6.024.3 ± 9.013.7 ± 4.3b1.8 ± 1.4c0.7 ± 0.7c
Ccr (ml/min)1.14 ± 0.320.69 ± 0.37b0.52 ± 0.23b0.33 ± 0.12b0.29 ± 0.28c
24-h urinary albumin (μg)428 ± 191306 ± 189121 ± 70b21 ± 19c11 ± 10c
  • a BUN, blood urea nitrogen; Ccr, creatinine clearance.

  • b P < 0.01,

  • c P < 0.001 compared to db/db controls.