Table 2.

Autoimmune tissue injury in 24-wk-old MLR lpr/lpr micea

ParameterSalineIRS 661IRS 954
Kidney injury
    activity index (score)14.8 ± 3.25.3 ± 1.7b7.0 ± 1.8b
    chronicity index (score)4.0 ± 1.81.0 ± 0.7b1.4 ± 1.0b
    glomerular C3 (score)2.4 ± 0.70.7 ± 0.3b0.9 ± 0.3b
        IgG1 (score)2.1 ± 0.22.1 ± 0.31.9 ± 0.3
        IgG2a (score)1.6 ± 0.60.7 ± 0.4b0.7 ± 0.3b
    glomerular Mac-2+ cells (cells/glomerulus)6.9 ± 2.42.0 ± 1.0b2.9 ± 1.5b
    interstitial Mac-2+ cells (cells/hpf)11.5 ± 3.23.7 ± 0.8b5.2 ± 5.0b
    interstitial CD3+ cells (cells/hpf)23.6 ± 5.312.5 ± 2.89.2 ± 3.1b
Urinary albumin/creatinine (mg/mg)4.3 ± 1.61.7 ± 0.82.6 ± 0.7
Lung injury (score)2.1 ± 0.51.0 ± 0.6b1.3 ± 0.6b
  • a n = 10 per group; data are means ± SEM. hpf, high-power field.

  • b P < 0.05 IRS 661 or 954 versus saline.