Table 1.

Clinical and histologic characteristics of biopsies from patients with early and established DN, LD, and patients with MCD analyzed by oligonucleotide array-based gene expression profiling and real-time RT-PCRa

Biopsy GroupGenderAge (yr)Histology Major DiagnosisCreatinine (mg/dl)Proteinuria (g/d)GFR (ml/min)HypertensionDiabetes TypeHbA1c (%)Retinopathy
Established DN
    DN3 (A + P)M57DN1.69.748Yes18.7Yes
    DN5 (A + P)F46DN2.40.423Yes27.5Yes
    DN6 (A + P)F67DN4.82.410Yes2NAYes
    DN9 (A)M67DN4.03.016Yes2NANA
    DN10 (A + P)M62DN2.35.039Yes27.8No
    DN11 (A + P)M68DN3.5NA34Yes27.2No
    DN16 (P)M58DN1.70.744Yes27.4No
    DN17 (P)M77DN2.93.126Yes2NANo
    DN18 (P)F59DN3.221.434Yes2NANA
    DN19 (P)M58DN2.414.248Yes29.8Yes
    DN20 (P)F63DN3.37.031Yes27.9No
    DN21 (P)M63DN2.18.651Yes27.1No
    DN22 (P)F47DN7.0NA9Yes213.8Yes
    DN23 (P)M74DN2.50.339Yes24.6No
    DN24 (P)F63DN2.96.536Yes26.4No
    DN25 (P)M55DN2.87.534Yes27.8Yes
    DN26 (P)M57DN1.61.468Yes28.8NA
    DN27 (P)M63DN3.00.625Yes26.2NA
    DN28 (P)M66DN9.81.76Yes26.0No
    DN29 (P)M60DN2.21.041Yes26.9No
    DN30 (P)M75DN1.76.240Yes27.3No
    DN31 (P)FNADN1.21060Yes2NANA
    DN32 (P)F63DN2.55.540Yes26.4NA
    mean ± SEM15/862.2 ± 1.73.1 ± 0.45.5 ± 1.234.9 ± 3.323/237.6 ± 0.5
Early DN
    DN1 (A)M45DN0.30.797No28.7Yes
    DN2 (A)F34DN1.40.951Yes17.5Yes
    DN4 (A)M61DN1.13.785Yes2NAYes
    DN7 (A)M73DN1.12.470Yes2NANA
    DN8 (A)M62DN1.22.554Yes27.8No
    mean ± SEM4/155 ± 6.91.1 ± 0.12.0 ± 0.671.4 ± 8.84/58.0 ± 0.4
LD
    LD1 (A)F66Normal tissue<1.1<0.2>100NoNoNANo
    LD2 (A)M26Normal tissue<1.1<0.2>100NoNoNANo
    LD3 (A)M49Normal tissue<1.1<0.2>100NoNoNANo
    LD4 (P)F35Normal tissue<1.1<0.2>100NoNoNANo
    LD5 (P)M39Normal tissue<1.1<0.2>100NoNoNANo
    LD6 (P)F55Normal tissue<1.1<0.2>100NoNoNANo
    LD7 (P)M41Normal tissue<1.1<0.2>100NoNoNANo
    LD8 (P)M61Normal tissue<1.1<0.2>100NoNoNANo
    LD9 (P)F58Normal tissue<1.1<0.2>100NoNoNANo
    LD10 (P)M27Normal tissue<1.1<0.2>100NoNoNANo
    LD11 (P)F54Normal tissue<1.1<0.2>100NoNoNANo
    LD12 (P)F61Normal tissue<1.1<0.2>100NoNoNANo
    CD5 (P)NANANormal tissue<1.1<0.2>100NoNoNANo
    mean ± SEM6/647.7 ± 4.0<1.1<0.2>1000/13
MCD
    MCD1 (A + P)M32MCD1.311.0104YesNoNANA
    MCD2 (A + P)F32MCD0.73.0121NoNoNANA
    MCD3 (A + P)M16MCD1.25.4102YesNoNANA
    MCD4 (A + P)M20MCD (remission)0.90.2122YesNoNANA
    MCD5 (P)F57MCD1.115.0102NoNoNANA
    MCD6 (P)M34MCD1.49.184NoNoNANA
    MCD7 (P)MNAMCD0.60.6NANoNANA
    mean ± SEM5/225 ± 4.11.0 ± 0.14.9 ± 2.3116.0 ± 5.83/7
  • a A, patients who were analyzed by oligonucleotide array-based gene expression profiling; DN, diabetic nephropathy; HbA1c, glycosylated hemoglobin; MCD, minimal-change disease; P, patients who were analyzed by real-time reverse transcriptase–PCR (RT-PCR).