Table 2.

Clinical and histologic characteristics of biopsies from patients with early and established DN and control kidneys analyzed by immunohistologic staining for VEGF, EGF, and PECAM-1/CD31a

Biopsy GroupGenderAge (yr)Histology Major DiagnosisCreatinine (mg/dl)Proteinuria (g/d)GFR (ml/min)Interstitial Fibrosis (%)Interstitial VEGF (%)Interstitial EGF (%)Interstitial CD31 (%)HbA1c (%)HypertensionRetinopathy
Early DN
    DN01M44DN0.90.71500151067.1YesNo
    DN02M64DN10.61080107128YesYes
    DN03M48DN11.5105081007.8YesNo
    DN04M50DN1.128020161208YesNo
    mean ± SEM4/451.5 ± 4.31.0 ± 0.041.2 ± 0.3110.8 ± 11.05.0 ± 5.012.0 ± 1.910.0 ± 1.05.0 ± 2.97.7 ± 0.24/41/3
Established DN
    DN05M56DN1.21.264321410107.4YesYes
    DN06M61DN1.62.1583512907.6YesNo
    DN07M63DN0.91.757201010115.5NoNo
    DN08M66DN0.8155287547.3YesNo
    DN09M59DN1.3140464005.4YesYes
    DN10M79DN2.41.6402210565.9NoNo
    mean ± SEM6/664.0 ± 3.31.4 ± 0.21.4 ± 0.252.3 ± 4.031.0 ± 3.910.0 ± 1.57.0 ± 1.65.0 ± 1.96.5 ± 0.44/62/4
Control kidneys
    NK01M57Normal tissue0.901000847330NAYesNo
    NK02M60Normal tissue0.809815756728NANoNo
    NK03M62Normal tissue10960867832NANoNo
    mean ± SEM3/360.0 ± 1.50.9 ± 0.198.0 ± 1.25.0 ± 5.082.0 ± 3.473.0 ± 3.230.0 ± 5.01/30/3
  • a PECAM-1, platelet-endothelial cell adhesion molecule-1; VEGF, vascular endothelial growth factor.