Table 3.

Microarray gene expression data of the 49 regulated genesa

Gene SymbolProbe Set IDFold ChangeQ Value (%)Gene Title
Upregulated genes
    ADAM10214895_s_at2.91210.1055ADAM metallopeptidase domain 10
    ADAM10202603_at1.63791.2069ADAM metallopeptidase domain 10
    ADAM17213532_at1.48110.9700ADAM metallopeptidase domain 17 (tumor necrosis factor, α, converting enzyme)
    ADAM9202381_at1.81850.0755ADAM metallopeptidase domain 9 (meltrin γ)
    AKR1B1201272_at1.91090.4272Aldo-keto reductase family 1, member B1 (aldose reductase)
    BMP1202701_at1.20630.5045Bone morphogenetic protein 1
    BMP6206176_at1.48373.8646Bone morphogenetic protein 6
    CASP1211366_x_at2.24260.0440Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, β, convertase)
    CASP1209970_x_at2.37250.0440Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, β, convertase)
    CASP1211368_s_at2.62790.0440Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, β, convertase)
    CCL21204606_at1.52041.9243Chemokine (C-C motif) ligand 21
    COL1A2202404_s_at2.76230.2614Collagen, type I, α2
    COL4A1211980_at3.02810.0440Collagen, type IV, α1
    COL4A1211981_at2.86700.0440Collagen, type IV, α1
    COL4A2211966_at2.19820.0440Collagen, type IV, α2
    COL4A2211964_at2.00890.1055Collagen, type IV, α2
    ELF1212418_at1.612810.0755E74-like factor 1 (ets domain transcription factor)
    ELF2203822_s_at1.28981.2069E74-like factor 2 (ets domain transcription factor)
    ELF3210827_s_at1.71530.5974E74-like factor 3 (ets domain transcription factor, epithelial-specific)
    ELK3221773_at3.23050.0440ELK3, ETS-domain protein (SRF accessory protein 2)
    ERG213541_s_at1.27473.8646v-ets erythroblastosis virus E26 oncogene like (avian)
    ETS2201328_at1.71250.3487v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
    FLII222065_s_at1.23360.5974Flightless I homolog (Drosophila)
    FN1211719_x_at4.03090.0440Fibronectin 1
    FN1216442_x_at3.11580.0440Fibronectin 1
    FN1212464_s_at3.46870.0440Fibronectin 1
    FN1210495_x_at3.22950.0440Fibronectin 1
    ICAM-1202637_s_at1.40900.1055Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
    ICAM-1202638_s_at1.52420.1709Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
    ICAM-2213620_s_at1.74711.9243Intercellular adhesion molecule 2
    MET203510_at1.84860.0440Met proto-oncogene (hepatocyte growth factor receptor)
    MET211599_x_at1.40210.5045Met proto-oncogene (hepatocyte growth factor receptor)
    MGC5618221477_s_at2.28020.1709Hypothetical protein MGC5618
    MMP-14160020_at1.20180.7642Matrix metallopeptidase 14 (membrane-inserted)
    MMP-14202827_s_at1.21501.9243Matrix metallopeptidase 14 (membrane-inserted)
    MMP-2201069_at1.28371.9243Matrix metallopeptidase 2 (gelatinase A, 72-kD gelatinase, 72-kD type IV collagenase)
    MMP-7204259_at14.27730.0440Matrix metallopeptidase 7 (matrilysin, uterine)
    NFKB-1209239_at1.20860.2131Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
    PECAM-1208982_at2.70410.0440Platelet/endothelial cell adhesion molecule (CD31 antigen)
    PECAM-1208981_at1.86520.0440Platelet/endothelial cell adhesion molecule (CD31 antigen)
    PECAM-1208983_s_at2.27190.0440Platelet/endothelial cell adhesion molecule (CD31 antigen)
    PLAT201860_s_at1.54063.8646Plasminogen activator, tissue
    SOD2215223_s_at2.37401.9243Superoxide dismutase 2, mitochondrial
    SPP1209875_s_at1.55680.7642Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
    TGFBI201506_at2.94950.0440Transforming growth factor, β -induced, 68 kD
    TGFBR2208944_at2.43630.0440Transforming growth factor, β receptor II (70/80 kD)
    TIMP1201666_at4.65790.0440TIMP metallopeptidase inhibitor 1
    TIMP3201149_s_at1.46670.2796TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    TIMP3201147_s_at1.26111.2069TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    VCAM-1203868_s_at2.13100.5045Vascular cell adhesion molecule 1
    VIM201426_s_at3.10980.0440Vimentin
    VWF202112_at3.42520.0440Von Willebrand factor
Downregulated genes
    ADRA2B208544_at0.79541.2069Adrenergic, α-2B-, receptor
    AGT202834_at0.40870.3487Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    BMP1206725_x_at0.80251.9243Bone morphogenetic protein 1
    EGF206254_at0.33690.0440Epidermal growth factor (β-urogastrone)
    ERF203643_at0.66360.0440Ets2 repressor factor
    KNG1206054_at0.56910.5974Kininogen 1
    MMP17206234_s_at0.81361.5560Matrix metallopeptidase 17 (membrane-inserted)
    SPDEF213442_x_at0.86800.9700SAM pointed domain containing ets transcription factor
    TGFBR3204731_at0.48990.1308Transforming growth factor, β receptor III (betaglycan, 300 kD)
    VEGF212171_x_at0.66420.0440Vascular endothelial growth factor
    VEGF210512_s_at0.44520.0440Vascular endothelial growth factor
    VEGF210513_s_at0.70160.1308Vascular endothelial growth factor
    VEGFB203683_s_at0.76991.5560Vascular endothelial growth factor B
  • a Comparison of a list of 202 genes, which might be involved in DN, revealed 49 genes with significantly altered expression levels in DN compared with controls (P < 0.05). Thirty-eight genes were upregulated, and 11 were downregulated.