Table 2.

Baseline histologic characteristicsa

Histologic LesionIntravenous Methylprednisolone (n = 49)Plasma Exchange(n = 51)Total Group(n = 100)
Glomerular
    % normal glomeruli13.6 ± 18.212.1 ± 12.112.8 ± 15.3
    % fibrinoid necrosis28.9 ± 25.322.2 ± 24.925.5 ± 25.2
    % crescents59.2 ± 28.653.0 ± 28.956.0 ± 28.8
        segmental23.1 ± 23.428.9 ± 31.325.9 ± 27.3
        circumferential76.9 ± 44.371.1 ± 54.374.1 ± 49.5
        cellular90.4 ± 49.190.8 ± 57.290.6 ± 53.0
        fibrous9.6 ± 12.69.2 ± 18.09.4 ± 15.3
    % global sclerosis24.6 ± 26.928.2 ± 24.626.4 ± 25.7
Tubulointerstitial and vascular
    interstitial edema (0/1)0.5 ± 0.50.5 ± 0.50.5 ± 0.5
    interstitial infiltrates (0/1/2/3)1.8 ± 0.71.8 ± 0.61.8 ± 0.7
        neutrophilic (0/1/2)0.7 ± 0.40.7 ± 0.50.7 ± 0.5
        mononuclear cell (0/1/2)1.8 ± 0.41.8 ± 0.41.8 ± 0.4
        eosinophilic (0/1/2)0.4 ± 0.50.3 ± 0.50.4 ± 0.5
    interstitial fibrosis (0/1/2)1.2 ± 0.61.3 ± 0.61.2 ± 0.6
    tubular casts (0/1)0.9 ± 0.30.9 ± 0.30.9 ± 0.3
    tubular necrosis (0/1)0.8 ± 0.40.8 ± 0.40.8 ± 0.4
    tubular atrophy (0/1/2)1.1 ± 0.51.2 ± 0.61.1 ± 0.6
    intraepithelial infiltrates (0/1)0.8 ± 0.40.8 ± 0.40.8 ± 0.4
    arteriosclerosis (0/1)0.8 ± 0.40.7 ± 0.40.8 ± 0.4
  • a The average distribution of the most characteristic glomerular, tubulointerstitial, and vascular lesions from 100 renal biopsies are described according to treatment group. This represents 75% of the 137 patients who were randomly assigned in this study. Glomerular lesions are expressed as a mean percentage ± SD of the total number of glomeruli per patient. All crescents were scored as either segmental or circumferential and as either cellular or fibrous, expressed as a percentage ± SD of the total number of crescents. Tubulointerstitial and vascular lesions were scored either in a dichotomous or in a semiquantitative manner. The numbers after every lesion indicate the possible scoring values.