Table 4.

Unadjusted OR of BP and laboratory variables ≤5th or ≥95th percentiles, compared by categories of GFR and race/ethnicitya

VariableGFRRace/Ethnicity (versus White)P
<60 versus ≥60 ml/min per 1.73 m2PBlackHispanicOtherRace/EthnicityRace/Ethnicity × GFR
SBP ≥156.0 mmHg
    all5.60 (4.47 to 7.02)<0.00011.53 (1.25 to 1.88)0.71 (0.58 to 0.87)0.86 (0.56 to 1.31)<0.0001<0.0001
    GFR <601.84 (1.27 to 2.66)1.97 (1.13 to 3.44)2.20 (1.35 to 3.58)0.0005
    GFR ≥601.61 (1.31 to 2.05)0.76 (0.63 to 0.92)0.79 (0.55 to 1.14)<0.0001
DBP ≥90.7 mmHg
    all1.54 (1.09 to 2.16)0.01471.93 (1.52 to 2.46)0.95 (1.52 to 2.46)1.01 (0.67 to 1.53)<0.00010.0010
    GFR <603.01 (1.79 to 5.05)1.77 (1.79 to 5.05)5.27 (1.91 to 14.55)0.0004
    GFR ≥601.89 (1.47 to 2.43)0.95 (0.73 to 1.22)0.87 (0.58 to 1.31)<0.0001
Potassium ≥4.6 mmol/L
    all4.03 (3.15 to 5.16)<0.00010.75 (0.57 to 0.90)0.63 (0.45 to 0.90)0.65 (0.40 to 1.08)0.00600.0006
    GFR <600.72 (0.36 to 1.43)1.29 (0.73 to 2.28)1.92 (1.22 to 3.01)0.0139
    GFR ≥600.79 (0.60 to 1.04)0.68 (0.48 to 0.96)0.58 (0.34 to 0.98)0.0229
Hemoglobin ≤118.0 g/L
    all2.21 (1.69 to 2.90)<0.00013.44 (2.46 to 4.82)1.37 (0.96 to 3.39)1.29 (0.77 to 2.17)<0.00010.7936
    GFR <603.96 (2.66 to 5.88)1.77 (0.88 to 3.59)1.77 (0.88 to 3.59)<0.0001
    GFR ≥603.54 (2.41 to 5.19)1.45 (0.97 to 2.17)1.38 (0.78 to 2.42)<0.0001
Bicarbonate ≤22.5 mmol/L
    all1.77 (1.27 to 2.48)0.00131.52 (1.10 to 2.09)2.03 (1.22 to 3.39)0.73 (0.39 to 1.38)0.00100.8822
    GFR <601.44 (0.73 to 2.87)2.34 (1.09 (5.05)0.92 (0.09 to 9.52)0.1344
    GFR ≥601.55 (1.12. to 2.15)2.11 (1.25 to 2.15)0.74 (0.36 to 1.54)0.0012
Calcium ≤2.1 mmol/L
    all0.83 (0.56 to 1.23)0.35370.99 (0.74 to 1.33)1.18 (0.83 to 1.68)1.66 (1.03 to 2.68)0.08180.4703
    GFR <601.99 (0.72 to 5.53)3.29 (1.13 to 9.58)1.91 (0.33 to 11.16)0.1391
    GFR ≥600.96 (0.72 to 1.28)1.14 (0.81 to 1.62)1.64 (1.03 to 2.63)0.0733
Phosphorus ≥1.4 mmol/L
    all1.73 (1.30 to 2.30)0.00031.46 (1.22 to 1.74)1.52 (1.27 to 1.83)1.19 (0.78 to 1.81)0.00010.4858
    GFR <601.42 (0.79 to 2.54)2.15 (1.07 to 4.32)0.64 (0.12 to 3.41)0.1334
    GFR ≥601.49 (1.24 to 1.79)1.57 (1.30 to 1.89)1.25 (0.82 to 1.92)0.0001
Uric acid ≥469.9 μmol/L
    all6.02 (4.91 to 7.39)<0.0011.42 (1.17 to 1.73)0.79 (0.61 to 1.02)1.18 (0.82 to 1.71)0.00080.0204
    GFR <603.03 (2.04 to 4.49)1.18 (0.61 to 2.28)2.55 (1.47 to 4.43)<0.0001
    GFR ≥601.38 (1.08 to 1.75)0.91 (0.69 to 1.18)1.18 (0.72 to 1.93)0.0338
≥1 abnormality
    all3.56 (3.00 to 4.23)<0.00011.74 (1.55 to 1.96)1.15 (1.02 to 1.31)0.97 (0.82 to 1.15)<0.00010.4277
    GFR <602.35 (1.49 to 3.70)1.83 (1.28 to 2.61)1.12 (0.57 to 2.22)0.0008
    GFR ≥601.80 (1.61 to 2.03)1.23 (1.08 to 1.40)1.01 (0.85 to 1.20)<0.0001
  • a Data are OR (95% CI). GFR values are given as ml/min per 1.73 m2. White race and GFR ≥60 were reference categories.