Patient | Initial P/C Ratios^{b} | Intercept of P/C Ratio Regression^{c} | Slope of P/C Ratios Regression | Follow-Up: Months on Agalsidase-β | No. of Complete Evaluations |
---|---|---|---|---|---|

CKD stages 1 and 2 | |||||

3 | 0.17 | 0.09 | −0.003 | 24.9 | 3 |

8 | 0.30 | 0.16 | 0.089 | 34.8 | 9 |

4 | 0.46 | 0.28 | −0.019 | 24.7 | 7 |

5 | 0.41 | 0.35 | 0.106 | 34.9 | 8 |

mean ± SD (median) | 0.34 ± 0.13 (0.36) | 0.22 ± 0.12 (0.22)^{d} | 0.043 ± 0.063 (0.043) | 29.8 ± 5.8 (29.8) | 6.8 ± 2.6 (7.5) |

CKD stages 3 and 4 | |||||

7 | 0.33 | 0.06 | 0.016 | 30.3 | 9 |

9 | 0.58 | 0.13 | 0.005 | 42.2 | 14 |

6 | 1.91 | 0.16 | 0.126 | 43.0 | 29 |

10 | 6.29 | 1.06 | 0.038 | 37.1 | 21 |

12 | 2.14 | 0.24 | 0.319 | 10.8 | 13 |

13 | 0.23 | 0.14 | 0.275 | 21.6 | 7 |

mean ± SD (median) | 1.91 ± 2.29 (1.24) | 0.30 ± 0.38 (0.15)^{e} | 0.130 ± 0.137 (0.082) | 28.1 ± 14.7 (29.4) | 15.5 ± 8.2 (13.5) |

↵

^{a}CKD, chronic kidney disease.↵

^{b}Value obtained before ACEI/ARB therapy was initiated.↵

^{c}Zero time assigned to the point at which ERT was initiated.↵

^{d}*P*= 0.0161, two-tailed*t*test, comparing fourth-root transformation of regression intercept to initial P/C ratio.↵

^{e}*P*= 0.0054, two-tailed*t*test, comparing fourth-root transformation of regression intercept to initial P/C ratio.