Table 5.

Individual patient regression analysis of eGFR over time

PatientInitial eGFR (ml/min per 1.73 m2)aIntercept of eGFR Regression (ml/min per 1.73 m2 per yr)bSlope of eGFR Regression (ml/min per 1.73 m2 per yr)
CKD stages 1 and 2
    3115121.42.229
    810483.91.164
    410295.8−2.617
    59686.23.947
    mean ± SD (median)104 ± 7.9 (103)96.9 ± 17.2 (91.0)1.18 ± 2.78 (1.70)
CKD stages 3 and 4
    75451.60.9890
    96743.00.444
    67349.4−1.918
    105033.2−1.135
    123022.3−0.322
    133836.80.580
    mean ± SD (median)52.0 ± 16.5 (52.0)39.4 ± 10.9 (39.9)c−0.23 ± 1.12 (0.06)
  • a Value before ACEI/ARB therapy was initiated.

  • b Zero time assigned to the point at which ERT was initiated.

  • c P = 0.0298, two-tailed t test, comparing the regression intercept to initial eGFR when ACEI/ABR therapy was started.