Table 2.

Quartiles of ACR (mg/g) and risk for incident hypertensiona

ParameterQuartiles (Median [Range])P (Trend)
1.0 (0.0 to 1.7)2.2 (1.7 to 2.7)3.4 (2.7 to 4.3)6.5 (4.3 to 24.2)
NHS I
    no. of participants246290299230
    no. of cases50708071
    multivariable RR (95% CI)1.00 (reference)1.31 (0.90 to 1.89)1.37 (0.95 to 1.97)1.76 (1.21 to 2.56)0.004
1.1 (0.0 to 1.6)2.0 (1.6 to 2.4)2.9 (2.4 to 3.7)5.4 (3.7 to 23.8)
NHS II
    no. of participants242300307265
    no. of cases63757979
    multivariable RR (95% CI)1.00 (reference)1.03 (0.73 to 1.45)1.13 (0.80 to 1.59)1.35 (0.97 to 1.91)0.060
  • a Adjusted for age, BMI, eGFR, baseline BP, physical activity, smoking, and family history of hypertension. RR, relative risk.