Table 2.

Association between SNP and newborn kidney volume or cord blood cystatin C

SNP IDGenotype Frequencies (%)KidVol/BSA (ml/m2)Cystatin C (mg/L)
rs1800860
    GG46.3139.4 ± 33.01.84 ± 0.30
    GA47.1126.3 ± 24.72.02 ± 0.33
    AA6.6123.0 ± 22.31.94 ± 0.14
    GA + AA53.7125.9 ± 24.3a2.01 ± 0.32b
rs1799939
    GG56.3131.3 ± 31.01.93 ± 0.32
    GA40.0134.1 ± 27.51.95 ± 0.33
    AA3.7132.1 ± 25.31.72 ± 0.30
    GA + AA43.7133.9 ± 27.1 (NS)1.93 ± 0.3 (NS)
  • Association between RET SNPs and newborn kidney volume or cord blood cystatin C. Normal term Caucasian newborns (136) from Montreal were genotyped for the rs1800860 (1476G/A) and rs1799939 (2251G/A) RET SNPs by sequence analysis of PCR amplicons. Genotype frequencies in our cohort are similar to those reported for the CAUC and CEU populations in the NCBI dbSNP database. Total renal volume adjusted for body surface area (KidVol/BSA) in newborns bearing one or more 1476(A) alleles was 9.7%, less than that of homozygous 1476(G/G) newborns (P = 0.009). Umbilical cordblood cystatin C concentration in newborns with one or more 1476(A) alleles was 9.2% higher than in homozygous 1476(G/G) babies (P = 0.002). The presence of a 2251(A) allele had no significant effect on KidVol/BSA (P = 0.60) or umbilical cord cystatin C (P = 0.91) compared with newborns with the homozygous 2251(G/G) genotype.

  • a P = 0.009.

  • b P = 0.002.