Table 3.

Electron microscopy features in relation to histologic diagnosis in 53 patients with C1q nephropathya

Electron Microscopy FeaturesLight Microscopy Findings (n [%])
No Lesions (n = 5)No Lesions (with NS) (n = 16)FSGS (with NS) (n = 7)Proliferative GN (n = 17)Other (n = 8)
Mesangial deposits4 (80.0)14 (87.5)3 (42.9)6 (35.3)7 (87.5)
Mesangial-SED deposits0 (0.0)1 (6.3)2 (28.6)3 (17.6)0 (0.0)
Mesangial-SED-SEP deposits0 (0.0)0 (0.0)0 (0.0)5 (29.4)0 (0.0)
Mesangial-SEP deposits0 (0.0)0 (0.0)1 (14.3)2 (11.8)0 (0.0)
Podocyte foot process effacementb
    ≥50%0 (0.0)7 (43.7)5 (71.4)2 (11.8)0 (0.0)
    <50%0 (0.0)7 (43.7)2 (28.6)7 (41.2)1 (14.3)
Podocyte cytoskeleton condensation0 (0.0)15 (93.8)6 (85.7)10 (58.8)0 (0.0)
  • a SED, subendothelial; SEP, subepithelial.

  • b Determined by estimation based on examination of the ultrastructure of nonsclerotic glomerular capillaries.