Table 6.

Clinical outcomes in relation to histologic diagnosis in 53 patients with C1q nephropathy

Clinical OutcomesLight Microscopy Findings
No Lesions (n = 6)No Lesions (with NS) (n = 13)FSGS (with NS) (n = 9)Proliferative GN (n = 14)Other (n = 11)a
Follow-up (yr; range)0.5 to 15.00.3 to 21.01.0 to 9.00.5 to 12.00.5 to 14.0
Follow-up (yr; mean ± SD)5.4 ± 6.07.1 ± 7.42.9 ± 2.54.9 ± 3.56.5 ± 4.7
Normal/complete remission (n [%])2 (33.3)10 (76.9)3 (33.3)2 (14.3)0 (0.0)
Partial remission (n [%])1 (16.7)3 (23.1)2 (22.2)0 (0.0)2 (18.2)
Treatment resistant NS (n [%])0 (0.0)0 (0.0)1 (11.1)0 (0.0)0 (0.0)
Stable renal disease (n [%])3 (50.0)0 (0.0)0 (0.0)8 (57.1)4 (36.4)
Progression of renal disease (n [%])0 (0.0)0 (0.0)0 (0.0)2 (14.3)2 (18.2)
ESRD (n [%])0 (0.0)0 (0.0)3 (33.3)2 (14.3)3 (27.2)
  • a Tubulointerstitial nephritis (n = 2), Hantavirus nephropathy (n = 1), benign hypertensive nephrosclerosis (n = 2), thin basement membrane nephropathy (n = 2), autosomal recessive polycystic kidney disease (n = 1), and medullary cystic disease (n = 1).