Table 2.

Multivariate analysis for the primary composite end point (including GFR; n = 4975)

ParameterHR (95% CI)P
Duration 5 to 10 yr (versus <5 yr)0.92 (0.769 to 1.094)0.3382
BMI (kg/m2)0.98 (0.968 to 0.996)0.0127
Triglycerides 1.7 to 2.2 mmol/l (versus <1.7 mmol/L)1.00 (0.844 to 1.183)0.9907
Age (yr)1.03 (1.017 to 1.036)<0.0001
Triglycerides >2.2 mmol/l (versus <1.7 mmol/l)1.16 (1.004 to 1.332)0.0438
Positive Micral test1.16 (1.024 to 1.312)0.0191
Duration ≥10 yr (versus <5 yr)1.20 (1.031 to 1.404)0.0188
LDL cholesterol 3 to 4 mmol/L (versus <3 mmol/L)1.22 (1.060 to 1.397)0.0053
Diuretic use1.24 (1.083 to 1.416)0.0018
Past smoker (versus never)1.25 (1.089 to 1.435)0.0015
CKD (GFR<60 ml/min per 1.73 m2)1.25 (1.048 to 1.490)0.0130
Previous stroke1.26 (1.074 to 1.486)0.0048
LDL cholesterol >4 mmol/L (versus <3 mmol/L)1.27 (1.060 to 1.517)0.0096
HbA1c ≥7.5%1.32 (1.157 to 1.515)<0.0001
Previous MI1.40 (1.222 to 1.606)<0.0001
Current smoker (versus never)1.49 (1.230 to 1.804)<0.0001
Peripheral arterial obstructive disease1.49 (1.275 to 1.737)<0.0001