Table 2.

Changes in serum biochemical parameters

ParameterSevelamer (n = 33)Calcium (n = 35)Pa
Baseline1 YrBaseline1 Yr
Phosphorus (mg/dl; mean ± SD)5.8 ± 1.55.4 ± 0.1.45.7 ± 1.85.3 ± 1.90.78
Calcium (mg/dl; mean ± SD)9.6 ± 0.79.1 ± 1.19.8 ± 1.09.3 ± 0.7b0.22
iPTH (pg/ml; median [range])167 (3 to 1958)275 (34 to 3890)113 (4 to 1369)227 (28 to 3636)b0.55
25-OH D (ng/ml; median [range])16.3 (5.0 to 34.6)20.0 (5.4 to 53.2)b16.6 (5.0 to 35.3)17.4 (5.0 to 49.1)0.53
1,25-OH2 D (pg/ml; median [range])6.4 (5.0 to 22.4)8.1 (4.5 to 83.5)11.8 (5.0 to 42.9)13.7 (4.5 to 61.5)0.27
Total cholesterol (g/L; mean ± SD)1.65 ± 0.381.40 ± 0.34b1.72 ± 0.411.66 ± 0.410.03
LDL cholesterol (g/L; mean ± SD)1.03 ± 0.340.68 ± 0.30b1.07 ± 0.371.00 ± 0.31<0.01
HDL cholesterol (g/L; mean ± SD)0.50 ± 0.120.55 ± 0.14b0.43 ± 0.120.49 ± 0.15b0.87
Bicarbonate (mmol/L; mean ± SD)19.3 ± 3.920.4 ± 3.319.7 ± 3.821.2 ± 4.10.34
BSAP (μg/L; median [range])11.5 (3.9 to 65.2)19.1 (3.9 to 174.0)b10.6 (3.4 to 80.1)12.7 (4.5 to 185.0)0.19
Osteocalcin (ng/ml; median [range])68.5 (2.9 to 896)84.2 (15.2 to 595)45.8 (2.4 to 308)123 (7.6 to 1122)b0.54
N-telopeptides (nM; median [range])135 (7 to 1200)298 (11 to 1200)b72 (8 to 1200)132 (10 to 1200)b0.87
  • a Between-group difference in change from baseline assessed using Wilcoxon rank sum test.

  • b P< 0.05 for within-group change from baseline assessed using Wilcoxon signed rank test. Initial lipid levels measured at screening, not baseline.