Differences in Markers of Oxidative Stress and Inflammation Between CKD and Controls Group
| Inflammatory/Oxidative Biomarkers | Control (mean ± SD; n = 43) | CKD (mean ± SD; n = 184) | Unadjusted Pa | Adjusted Pb |
|---|---|---|---|---|
| Plasma F2-isoprostanes (ng/ml)c | 0.050 ± 0.033 | 0.081 ± 0.049 | <0.001 | <0.001 |
| Protein thiols (μ mol/L)c | 328.4 ± 33.3 | 304.0 ± 55.2 | <0.001 | 0.050 |
| CRP (mg/L)c | 2.2 ± 1.9 | 5.5 ± 7.6 | <0.001 | 0.010 |
↵a Mann-Whitney U test for unadjusted analysis between groups.
↵b P values were obtained using multivariable linear regression adjusted for age, gender, race, BMI, eGFR, history of diabetes, systolic BP, history of smoking, total cholesterol, and serum albumin.
↵c Log10 transformed dependent variable in multivariable linear regression model.