Table 2.

Chronic kidney disease and incident early AMD

Chronic Kidney Disease StageIncident Early AMDOdds Ratio (95% confidence interval)
No. at RiskNo. (%) AffectedAge-, Sex-, CFH Y402H Polymorphism-AdjustedPMultivariable AdjustedaP
No/mild (eGFRCG ≥ 60)89735 (3.9)1.01.0
Moderate (eGFRCG < 60)28650 (17.5)3.2 (1.8–5.7)<0.00013.0 (1.6–5.4)0.0004
P<0.0001
  • AMD, age-related macular degeneration; eGFRCG, estimated glomerular filtration rate (in ml/min/1.73m2) using the Cockcroft-Gault formula.

  • a Adjusted for age (continuous), sex, hypertension (present, absent), systolic blood pressure, diastolic blood pressure (both continuous), diabetes (present, absent), cigarette smoking (current, ex), pack-yr of cigarette smoking, white cell count, plasma fibrinogen, fasting plasma cholesterol, fasting plasma triglycerides (all continuous), CFH Y402H genotype (homozygous, heterozygous, noncarrier), and body mass index (continuous).