Table 3.

Estimated glomerular filtration rate and incident early AMD

Incident Early AMDOdds Ratio (95% confidence interval)
No. at RiskNo. (%) AffectedAge-, Sex-, CFH Y402H Genotype-AdjustedPMultivariable AdjustedaP
Per SD decrease eGFRCG118385 (7.2)2.0 (1.4–2.8)<0.00012.0 (1.5–2.8)<0.0001
By CFH Y402H genotype
    in noncarriers/heterozygotes (YY/YH)69659 (8.5)1.8 (1.2–2.6)0.0031.7 (1.2–2.6)0.008
    in homozygotes (HH)48726 (5.3)2.5 (1.3–4.8)0.0062.6 (1.3–5.3)0.009
Per SD decrease eGFRMDRD118385 (7.2)1.6 (1.3–2.1)0.00021.6 (1.3–2.1)0.0001
Per SD increase serum creatinine1.3 (1.1–1.5)0.0081.3 (1.1–1.5)0.008
  • Units in either ml/min/1.73m2 (eGFR) or mg/dl (creatinine). AMD, age-related macular degeneration; eGFRCG and eGFRMDRD, estimated glomerular filtration rate (in ml/min/1.73m2) using the Cockcroft-Gault and MDRD formulae, respectively; SD, standard deviation (14.8 ml/min/1.73m2 for eGFRCG; 12.5 ml/min/1.73m2 for eGFRMDRD; 0.24 mg/dl for creatinine).

  • a Adjusted for age (continuous), sex, hypertension (present, absent), systolic blood pressure, diastolic blood pressure (both continuous), diabetes (present, absent), cigarette smoking (current, ex), pack-yr of cigarette smoking, white cell count, plasma fibrinogen, fasting plasma cholesterol, fasting plasma triglycerides (all continuous), CFH Y402H genotype (homozygous, heterozygous, noncarrier), and body mass index (continuous).