Table 2.

Effects of treatment with placebo, losartan, and losartan + HCT during HS and LS

Parameter (n = 33)PlaceboLosartanLosartan + HCT
Serum creatinine (μ mol/L)
    HS125 (8)121 (7)136 (9)a,b
    LS126 (7)129 (7)c,d143 (10)a,b
Serum urea (mmol/L)
    HS7.0 (0.4)7.6 (0.5)9.9 (0.9)a,b
    LS6.9 (0.5)7.6 (0.6)b,d10.8 (1.1)a,b
Serum potassium (mmol/L)
    HS4.3 (0.1)4.4 (0.1)4.1 (0.1)a,b
    LS4.3 (0.1)4.5 (0.1)b,d4.0 (0.1)a,b
Serum total cholesterol (mmol/L)
    HS6.1 (0.3)e5.7 (0.2)5.8 (0.2)
    LS5.9 (0.2)5.5 (0.2)b,d5.6 (0.3)b
Serum total protein (g/L)
    HS68.9 (1.4)68.0 (1.3)69.8 (1.2)a,b
    LS69.2 (1.4)70.1 (1.1)c72.3 (1.1)a,b,c
Serum albumin (g/L)
    HS38.7 (0.7)38.8 (0.6)39.7 (0.6)a
    LS39.0 (0.7)40.1 (0.6)b,c41.0 (0.5)a,b,c
Serum uric acid (mmol/L)
    HS0.42 (0.01)0.39 (0.01)0.46 (0.02)a,b
    LS0.43 (0.02)0.42 (0.02)d0.52 (0.02)a,b,c
Plasma aldosterone (pg/ml)
    HS93 (15)78 (12)113 (12)a
    LS140 (17)c132 (13)c,d189 (18)a,b,c
Plasma renin (ng AI/ml per h)
    HS4.2 (0.4)e11.1 (2.1)b20.1 (2.8)a,b
    LS5.2 (0.5)16.6 (2.5)b,c,d37.2 (4.4)a,b,c
Aldosterone-renin ratio (pg/ng AI × h)
    HS29 (5)15 (5)b10 (2)a,b
    LS36 (7)16 (5)b,d7 (1)a,b,c
  • a P < 0.05 versus losartan treatment on same diet (effect of HCT).

  • b P < 0.05 versus placebo on same diet.

  • c P < 0.05 versus same treatment on HS (effect of LS).

  • d P < 0.05 versus losartan + HCT HS (comparison between addition of LS and HCT with losartan).

  • e P < 0.05 versus all periods.