Table 3.

Baseline characteristics according to the antiproteinuric response to losartan from baselinea

Parameter (n = 33)Resistant (n = 16)Intermediate (n = 10)Good (n = 7)
Male/female (n)11/58/25/2
Age (yr)54 (3)47 (3)47 (6)
BMI (kg/m2)28 (1)28 (2)25 (1)
Creatinine clearance (baseline; ml/min)88 (7)93 (8)85 (14)
Mean urinary sodium excretion on HS (mmol/d)200 (11)202 (20)177 (10)
Mean urinary sodium excretion on LS (mmol/d)88 (7)93 (8)85 (14)
BP response to losartan on HS (%)6.2 (2.3)4.9 (1.9)8.1 (2.6)
Patients on additional antihypertensive drugs (n)4/162/101/7
  • a For examination of whether patients who are resistant to RAAS blockade have any specific benefits of sodium depletion, patients were divided into three groups: resistant (<25% reduction in proteinuria; n = 16), intermediate (25 to 50% reduction; n = 10), and good responders (>50% reduction; n = 7) according to their antiproteinuric response to losartan from baseline (on placebo-HS). BMI, body mass index.