Table 2.

The 37 urinary biomarkers that statistically differentiated 104 patients randomly selected from the group of 147 patients with nondiabetic chronic renal diseases from a cohort composed of 70% of patients with clinically confirmed diabetic nephropathya

PolypeptidePDiabetic NephropathyNondiabetic Chronic Renal DiseaseSequenceProtein
IDMass (Da)CE Time (min)UnadjustedmaxTBonferroniFrequencyMean AmplitudeFrequencyMean Amplitude
175343b5574.2523.208.77E-060.02135.01E-030.551.550.431.06
140401b3669.6724.171.90E-070.00171.10E-040.822.510.481.26
1401123657.6740.711.07E-050.01756.23E-030.320.820.721.95
130855b3363.5430.228.03E-080.00064.66E-050.802.10.420.94
1299403333.7223.833.34E-060.04561.91E-030.551.530.290.67
1214443081.4229.831.69E-050.03019.82E-030.230.450.521.24
110175b2802.8236.343.94E-140.00012.29E-110.070.140.561.31
107858b2751.3429.231.14E-060.00436.62E-040.200.520.611.52
107763b2748.7936.388.12E-150.00014.72E-120.090.140.601.18
1070162733.7834.168.38E-120.00014.87E-090.070.140.521.13
992512574.0132.813.86E-070.00272.24E-040.160.290.531.04
977362551.1534.728.65E-060.03154.94E-030.571.240.842.09
903442377.1020.801.29E-050.01857.49E-030.451.170.772.29GKNGDDGEAGKhPGRPhGERGPPhGPQCollagen α-1 (I) chain (227 to 250; Homo sapiens)
882822339.0034.013.74E-050.04382.18E-020.521.210.822.21
80012b2191.9922.396.40E-120.00013.72E-090.140.310.631.62NGDDGEAGkPGRpGERGPpGPQCollagen α-1 (I) chain
72521b2046.8130.721.89E-050.03511.10E-020.230.450.511.26
72161b2039.1321.781.92E-130.00011.11E-100.140.310.611.83SGSVIDQSRVLNLGPITRKUromodulin (589 to 607; Homo sapiens)
673821936.8734.751.53E-050.02758.89E-030.200.40.531.13GEKGPSGEAGTAGPPGTPGPQGCollagen α-2 (I) chain (844 to 865; Homo sapiens)
649051893.0328.863.02E-050.04291.75E-020.270.650.631.57
64431b1885.6538.821.73E-050.02761.01E-020.230.470.611.29
63427b1865.8132.982.73E-090.00031.59E-060.180.340.621.31DAGPAGPKGEPhGSPhGENGAPhGCollagen α-1 (I) chain (279 to 299; Homo sapiens)
623871844.4834.273.82E-070.00252.22E-040.180.430.581.39
57265b1732.7728.181.08E-060.00236.30E-040.551.690.933.04
56884b1725.5938.325.12E-050.04942.97E-020.521.520.882.62
565141716.7728.003.09E-060.00601.79E-030.451.040.792.07
55637b1698.5737.733.60E-060.00822.09E-030.270.680.631.79
458631549.7039.492.28E-050.03661.32E-020.180.430.531.21
448021526.6923.922.62E-060.00651.52E-030.230.480.621.31
423781486.6821.151.39E-090.00028.09E-070.110.280.591.35
42304b1485.6723.777.18E-060.00724.17E-030.641.760.942.81DGQPhGAKGEPhGDAGAKCollagen α-1 (I) chain (820 to 835; Homo sapiens)
363501396.6226.671.04E-050.01946.01E-030.180.380.531.07
339731353.6625.632.10E-050.02411.22E-020.611.310.872.16
324701326.5529.201.18E-060.00446.86E-040.230.480.621.36SpGGpGSDGKpGPpGCollagen type 3 α1
323431324.5928.707.45E-070.00324.33E-040.772.040.400.95TGPGGDKGDTGPpGPCollagen α-1 (III) chain
207501141.5224.511.89E-070.00171.10E-040.200.390.591.29
19791b1128.4925.651.48E-080.00038.59E-060.340.760.811.93
16497b1078.4727.761.01E-050.01955.89E-030.250.460.551.20
  • a Shown are the protein/peptide identification number in the data set (ID), mass (in Da) and normalized migration time (CE Time), the P values (unadjusted and adjusted using maxT and Bonferroni), and the frequency and mean amplitude in the two groups, diabetic nephropathy (DN) and other chronic renal disease (CRD). Where available, sequence and original protein are shown.

  • b Subsequently used in the classification model.