Table 2.

The acute natriuretic effect of DEX is not affected by VSM GR KOa

ParameterBaseline16 h after DEX
Control
    Na+0.58 ± 0.070.83 ± 0.09
    Cl1.03 ± 0.071.08 ± 0.10
    K+1.32 ± 0.101.22 ± 0.12
    urine volume1600 ± 1971566 ± 162
Sm-22 Cre+
    Na+0.55 ± 0.091.03 ± 0.18
    Cl0.90 ± 0.081.19 ± 0.16
    K+1.12 ± 0.121.20 ± 0.10
    urine volume1461 ± 952113 ± 213
  • a Urine electrolyte excretion, normalized to creatinine, was measured at baseline and acutely after DEX treatment in Sm-22 Cre+ GRloxP/loxP mice (n = 8) and controls (n = 6; see the Concise Methods section). Control mice develop a significant natriuretic response acutely after DEX administration. This response is unaltered in VSM GR KO mice. Electrolyte values are expressed as mmol/mg creatinine, and urine volume is expressed in μ l.