Table 3.

Adjusted HR, comparing calcitriol users with matched control patientsa

ParameterMortalityMortality or Long-Term Dialysis
Adjusted HR (95% CI)PAdjusted HR (95% CI)P
Model 10.76 (0.60 to 0.95)0.0140.86 (0.71 to 1.04)0.120
Model 20.67 (0.53 to 0.85)<0.0010.73 (0.60 to 0.90)0.003
Model 30.74 (0.58 to 0.95)0.0160.80 (0.65 to 0.99)0.038
As-treated model 3b0.76 (0.58 to 0.99)0.0440.80 (0.64 to 1.01)0.060
  • Model 1 adjusted for age, gender, and race and stratified by VA site. Model 2 adds baseline PTH level, eGFR, diabetes, coronary heart disease, and the Charlson comorbidity index. Model 3 adds use of an ACEI, ARB, statin, erythropoietin, or oral calcium; body mass index; systolic BP; serum levels of albumin, calcium, and phosphate; and number of nephrology visits in the previous year. HR, hazard ratio.

  • b As-treated model censors control patients at first oral calcitriol prescription.