Table 1.

Biochemical parameters in the various groups of animals

ParameterGroup 1Group 2Group 3Group 4Group 5Group 6Group 7Group 8Group 9Group 10
Mouse strainC57BL6(wild-type)LDLR−/−LDLR−/−LDLR−/−LDLR−/−LDLR−/−LDLR−/−LDLR−/−LDLR−/−LDLR−/−
DietRegular chowRegular chowHigh fatFatFatFatFatFatFatFat
SurgeryShamShamShamCKDCKDCKDCKDCKDCKDCKD
Weeks postnatal28282822282828282828
TreatmentVehicleVehicleVehicleVehicleVehicleCalcitriol 10 ng/kgCalcitriol 20 ng/kgParicalcitol 50 ng/kgParicalcitol 100 ng/kgParicalcitol 400 ng/kg
n77767661089
Presurgical weight18.983 ± 1.01019.314 ± 0.64019.400 ± 0.62021.740 ± 0.75021.500 ± 1.89022.120 ± 2.18021.400 ± 0.83521.020 ± 0.67621.988 ± 1.08922.378 ± 0.691
Weight at killing21.583 ± 0.75920.580 ± 0.50025.044 ± 1.64021.640 ± 0.95021.067 ± 1.80022.600 ± 1.86024.383 ± 1.80722.580 ± 1.03922.938 ± 1.32724.933 ± 1.205
BUN (mg/dl)20.960 ± 2.89627.660 ± 4.64018.700 ± 1.66061.200 ± 14.460a37.420 ± 3.740a54.000 ± 10.000a46.400 ± 3.280a38.140 ± 4.890a49.660 ± 2.690a38.710 ± 5.720a
Glucose (mg/dl)b148.410 ± 12.780233.500 ± 20.790155.900 ± 24.480124.800 ± 16.850165.430 ± 14.700207.870 ± 41.260181.400 ± 25.880184.430 ± 26.240174.500 ± 32.910288.140 ± 52.790
Cholesterol (mg/dl)52.360 ± 4.600199.00 ± 6.800658.900 ± 78.000c556.000 ± 70.000c702.500 ± 72.00c466.620 ± 50.600c790.800 ± 167.550c814.000 ± 90.720c593.500 ± 81.590c1213.2008 ± 143.550c
PTH (pg/ml)19.100 ± 5.30025.630 ± 6.30023.510 ± 13.360743.520 ± 186.000d444.050 ± 98.000d74.600 ± 8.300e44.320 ± 9.600e83.710 ± 18.800e60.340 ± 19.200e16.200 ± 2.700e
  • a All of the CKD groups had significantly higher BUN at killing compared with wild-type or high-fat sham (P < 0.02).

  • b There was no statistical difference among the glucose values.

  • c All the high fat–fed groups had significantly higher cholesterol compared with wild-type (P < 0.001).

  • d The PTH values were higher for the CKD groups compared with wild-type (P < 0.001).

  • e There was a dosage-dependent decrease in PTH compared with the CKD 28-wk vehicle group (untreated; P < 0.001).