Table 2.

Summary of studies that evaluated the predictive value of BNP or NT-pro-BNP for coronary artery disease, hypervolemia, and mortality in CKD

AuthorPatientsEnd PointAUCBest Cutoff
Goto et al.,50 200253 HDPrevious cardiac events0.788BNP: 390 pg/ml (sens 62%, spec 93%)
deFilippi et al.,27 2005207 with stages 1 through 5 CKDPrevious coronary artery disease0.69NT-pro-BNP: 318 pg/ml (sens 78%, spec 56%)
Khan et al.,28 200654 with CKDCoronary artery disease0.80 (NT-pro-BNP) 0.82 (BNP)NT-pro-BNP: 979 pg/ml (sens 79%, spec 70%, PPV 48%, NPV 90%)
BNP: 228 pg/ml (sens 86%, spec 73%, PPV 52%, NPV 94%)
Takami et al.,29 2004103 with CKDLV overload0.73BNP: 150 pg/ml (sens 52%, spec 93%)
Sommerer et al.,52 2007134 HDHypervolemia0.815NT-pro-BNP: 5300 pg/ml (sens 77%, spec 77%)
Madsen et al.,32 2007109 HDDeath0.718 (pre-HD)0.729 (post-HD)NT-pro-BNP: 4079 pg/ml (sens 82%, spec 61%)
Sharma et al.,53 200750 HD and 29 PDDeath0.74NT-pro-BNP: 350 pg/ml (sens 72%, spec 76%)