Table 3.

Adjusted incidence rate ratio (95% confidence interval) of cardiovascular and all-cause mortality, by category of eGFR: NHANES IIIa

ParametereGFR (ml/min per 1.73 m2)
≥12090 to 11975 to 8960 to 7445 to 5930 to 4415 to 29
All-cause mortality
eGFR based on:
    creatinine, age, race, and gender1.36 (1.01 to 1.82)1.00 (Ref)0.92 (0.78 to 1.08)0.98 (0.83 to 1.16)1.31 (1.09 to 1.56)1.80 (1.46 to 2.24)2.43 (1.67 to 3.53)
    cystatin C1.06 (0.67 to 1.68)1.00 (Ref)1.07 (0.88 to 1.30)1.53 (1.27 to 1.84)1.97 (1.62 to 2.41)2.76 (2.21 to 3.45)3.97 (2.93 to 5.39)
    cystatin C, age, race, and gender0.90 (0.54 to 1.50)1.00 (Ref)0.89 (0.71 to 1.11)1.21 (0.98 to 1.51)1.53 (1.22 to 1.92)2.45 (1.93 to 3.13)3.46 (2.56 to 4.68)
    creatinine, cystatin C, age, race, and gender1.16 (0.78 to 1.73)1.00 (Ref)0.96 (0.80 to 1.15)1.13 (0.94 to 1.36)1.54 (1.26 to 1.87)2.00 (1.61 to 2.50)2.86 (2.03 to 4.03)
Cardiovascular mortality
eGFR based on:
    creatinine, age, race, and gender0.83 (0.44 to 1.56)1.00 (Ref)1.01 (0.78 to 1.31)1.06 (082 to 1.37)1.42 (1.08 to 1.87)2.19 (1.61 to 2.99)2.54 (1.46 to 4.41)
    cystatin C0.95 (0.38 to 2.38)1.00 (Ref)1.21 (0.86 to 1.69)1.83 (1.34 to 2.51)2.73 (1.97 to 3.79)3.56 (2.49 to 5.08)5.47 (3.47 to 8.63)
    cystatin C, age, race, and gender0.93 (0.33 to 2.63)1.00 (Ref)1.13 (0.76 to 1.69)1.49 (1.02 to 2.19)2.13 (1.44 to 3.14)3.56 (2.37 to 5.36)4.40 (2.69 to 7.18)
    creatinine, cystatin C, age, race, and gender1.18 (0.53 to 2.61)1.00 (Ref)1.16 (0.84 to 1.59)1.48 (1.09 to 2.01)2.01 (1.46 to 2.77)2.83 (2.00 to 4.00)3.94 (2.39 to 6.49)
  • aAdjusted for age, gender, race/ethnicity, previous CVD, BP category, use of antihypertensive medication, diabetes status, smoking status, body mass index, LDL and HDL cholesterol, log triglycerides, and CRP category.