Table 2.

SBP, renal functional parameters, and histology in rats with renal mass reduction treated with vehicle or bortezomiba

ParameterRMR + VehicleRMR + Bortezomib
SBP (mmHg)182 ± 9165 ± 9
Proteinuria (mg/24 h)251 ± 43201 ± 67
Serum creatinine (mg/dl)0.95 ± 0.061.07 ± 0.09
Sclerotic glomeruli (%)22 ± 511 ± 2
  • a Data are means ± SEM. RMR + vehicle (n = 11); RMR + bortezomib (n = 10). SBP, systolic blood pressure.