Table 3.

Effect of proteasome inhibition on interstitial infiltrates in RMRa

ParameterControlRMR + Vehicle (No. of Cells/HPF)RMR + Bortezomib (No. of Cells/HPF)
ED15.70 ± 1.2021.87 ± 8.84b8.73 ± 2.97c
OX620.33 ± 0.267.11 ± 1.89b2.24 ± 1.02d
W3/256.13 ± 1.6554.24 ± 8.90b23.99 ± 9.41d
OX83.16 ± 0.7411.08 ± 5.54b3.74 ± 1.91c
  • a Data are means ± SEM. Control (n = 4); RMR + vehicle (n = 6); RMR + bortezomib (n = 5). ED1, monocytes/macrophages; HPF, high-power field; OX62, DC; OX8, CD8 T cells; W3/25, CD4 T cells/macrophages.

  • b P < 0.05 versus control.

  • c P < 0.05 versus RMR + vehicle.

  • d P < 0.01 versus RMR + vehicle.