Table 1.

Characteristics of participants according to quartiles of change in eGFR from visit 1 to visit 2

CharacteristicQuartiles of % Annual Change in eGFR
Q1 (−52.76 to −5.65; n = 3258)Q2 (−5.65 to −0.47; n = 3257)Q3 (−0.47 to −0.33; n = 3257)Q4 (−0.33 to 42.94; n = 3257)
Age (yr; mean ± SD)54.0 ± 5.853.8 ± 5.853.2 ± 5.154.9 ± 6.0
Male gender (%)32.351.740.747.1
Black race (%)27.825.820.424.4
Educational level (%)a
    <12 yr completed22.420.718.422.2
    12 to 16 yr completed41.840.742.941.5
    >16 yr completed35.838.638.736.3
Current smokers (%)a24.723.724.124.9
Current alcohol drinkers (%)a54.457.761.157.4
BMI (kg/m2; mean ± SD)a27.5 ± 5.527.5 ± 4.927.3 ± 5.227.9 ± 5.4
Diabetes mellitus (%)12.28.68.011.5
Antihypertensive medication (%)a28.526.424.929.9
ACEI (%)a3.02.72.73.0
SBP (mmHg; mean ± SD)a121.9 ± 20.1121.2 ± 17.8118.5 ± 16.9120.3 ± 17.5
DBP (mmHg; mean ± SD)a73.5 ± 11.474.4 ± 10.972.8 ± 10.673.3 ± 10.7
LDL cholesterol (mg/dl; mean ± SD)a134.0 ± 38.8137.9 ± 39.1136.9 ± 38.5138.7 ± 39.1
HDL cholesterol (mg/dl; mean ± SD)a53.7 ± 17.351.3 ± 16.352.8 ± 17.451.4 ± 16.9
TG (mg/dl; median [IQR])a106 (75, 152.5)107 (78, 152)106 (78, 152)113 (80, 158)
Left ventricular hypertrophy (%)a2.42.01.22.0
Carotid atherosclerosis (%)a8.57.45.57.0
Serum creatinine (mg/dl; mean ± SD)
    visit 10.75 ± 0.200.87 ± 0.150.85 ± 0.170.93 ± 0.19
    visit 20.96 ± 0.470.97 ± 0.160.85 ± 0.170.84 ± 0.18
eGFR (ml/min per 1.73 m2; mean ± SD)
    visit 1105.9 ± 23.291.5 ± 16.091.1 ± 16.984.0 ± 17.0
    visit 280.3 ± 18.580.0 ± 14.090.1 ± 16.794.3 ± 20.5
  • All comparisons were significant at P < 0.001, except for current smoking (P = 0.016), angiotensin-converting enzyme inhibitors (ACEI; P = 0.829), and left ventricular hypertrophy (P = 0.002). BMI, body mass index; SBP, systolic BP; DBP, diastolic BP; IQR, interquartile range; TG, triglycerides.

  • aMissing values (number missing): Educational level, 20; current smokers, 8; current drinkers, 43; BMI, 7; diabetes, 19; antihypertensive medication, 6; ACEI, 1; SBP, 3; DBP, 4; LDL cholesterol, 258; HDL cholesterol, 84; TG, 83; left ventricular hypertrophy, 303; carotid atherosclerosis, 386.