Table 2.

Adjusted HRs (95% CIs) of CHD and all-cause death by quartiles of % annual change in eGFR from visit 1 to visit 2, overall, and eGFR category at visit 1

OutcomesQuartiles of % Annual Change in eGFR
Q1 (−52.76 to −5.65)Q2 (−5.65 to −0.47)Q3 (−0.47 to −0.33)Q4 (−0.33 to 42.94)
All
    na3016301230042985
    CHD1.30 (1.11 to 1.52)1.16 (1.00 to 1.35)Reference1.04 (0.90 to 1.22)
    all-cause mortality1.22 (1.06 to 1.41)1.05 (0.92 to 1.21)Reference1.10 (0.96 to 1.27)
eGFR ≥90 ml/min per 1.73 m2
    na226213631247826
    CHD1.13 (0.91 to 1.41)1.19 (0.95 to 1.49)Reference0.98 (0.75 to 1.28)
    all-cause mortality0.96 (0.80 to 1.16)0.93 (0.76 to 1.13)Reference1.00 (0.80 to 1.23)
eGFR 60 to <90 ml/min per 1.73 m2
    na716160417201996
    CHD1.39 (1.09 to 1.76)1.10 (0.90 to 1.36)Reference1.06 (0.87 to 1.29)
    all-cause mortality1.40 (1.12 to 1.76)1.10 (0.90 to 1.35)Reference1.18 (0.97 to 1.42)
eGFR 30 to <60 ml/min per 1.73 m2
    na374437163
    CHD1.47 (0.46 to 4.67)1.68 (0.56 to 4.99)reference1.16 (0.43 to 3.10)
    all-cause mortality4.69 (1.28 to 17.16)4.98 (1.36 to 18.25)reference2.52 (0.73 to 8.74)
  • Adjusted for following covariates at visit 1: Age, race, gender, level of education, carotid atherosclerosis, SBP, antihypertensive medication, diabetes, smoking, alcohol intake, BMI, LDL cholesterol, HDL cholesterol, left ventricular hypertrophy, and eGFR.

  • aParticipants included in the fully adjusted analysis.