Table 3.

Joint associations of rapid kidney function decline and CKD status with cardiovascular events in the elderly

ParameterRapid DeclineInteraction P
No CKDCKD
NoYesNoYes
HF
    rates (events/1000 patient-years)25285269
    adjusted HR1.00 (reference)1.01 (0.80 to 1.27)1.58 (1.32 to 1.90)1.96 (1.57 to 2.44)0.82
MI
    rates (events/1000 patient-years)14192133
    adjusted HR1.00 (reference)1.31 (0.99 to 1.75)1.24 (0.95 to 1.62)1.74 (1.28 to 2.37)0.35
Stroke
    rates (events/1000 patient-years)15192426
    adjusted HR1.00 (reference)1.18 (0.90 to 1.55)1.32 (1.03 to 1.69)1.20 (0.87 to 1.64)0.60
PAD
    rates (events/1000 patient-years)2.84.34.35.7
    adjusted HR1.00 (reference)1.87 (1.00 to 3.50)1.46 (0.76 to 2.78)1.81 (0.88 to 3.72)0.68
  • Multivariate adjustment: HF = adjusted for age, gender, race, SBP, DBP, and hypertension medications, and diabetes; MI = adjusted for age, gender, race, SBP, DBP, hypertension medications, HDL, and diabetes; stroke = adjusted for age, gender, race, SBP, DBP, hypertension medications, self-reported health, and diabetes; PAD = adjusted for age, gender, race, SBP, DBP, hypertension medications, diabetes, HDL, fibrinogen, and self-reported health.