Table 1.

Pathologic findings in MPO-deficient micea

GroupMice with Crescents (% [n])% Glomeruli with Crescents per Mouse% Glomeruli with Necrosis per Mouse (Mean ± SEM)% Engraftment with MPO-Positive PMN (Mean ± SEM)
Mean ± SEMRange (%)Mean ± SEMRange (%)Mean ± SEMRange (%)
WT100 (6/6)b11.3 ± 3.4b5.4 to 24.16.1 ± 1.8b3.2 to 14.591.3 ± 3.280 to 100
C5aR−/−12.5 (1/8)0.5 ± 0.30.0 to 2.10.0 ± 0.091.5 ± 6.382 to 100
  • a Mice received WT or C5aR−/− BM.

  • b P < 0.01.