Table 4.

Percentage reduction in CrCl required to achieve a given SCr-based definition of AKI over a given period (12, 24, or 48 h), according to the presence or absence of CKDa

TimeSCrRIFLE1
Rise (mg/dl)No CKD (%)Stage 2 CKD (%)Stage 3 CKD (%)Stage 4 CKD (%)ClassNo CKD (%)Stage 2 CKD (%)Stage 3 CKD (%)Stage 4 CKD (%)
12 h0.337353333R47599854
0.555535254I779854
1.0878994100F54
24 h0.329252019R37425930
0.543373230I58679130
1.065615757F83999130
48 h0.327211411R34354219
0.539312319I51546319
1.057504034F70766319
1.568625449
  • a The absolute rise in SCr required for RIFLE “R” was 0.4, 0.6, 1.1, and 0.5 mg/dl for no CKD (baseline SCr 0.8), stage 2 CKD (baseline SCr 1.2), stage 3 CKD (baseline SCr 2.1), and stage 4 CKD (baseline SCr 3.8), respectively; for RIFLE “I” 0.8, 1.2, 1.9, and 0.5 mg/dl; and for RIFLE “F” 1.6, 2.3, 1.9, and 0.5 mg/dl, respectively. Missing values denote that AKI cannot be reached within the time frame specified even with 100% reduction in CrCl.