Table 3.

HRs for progression to ESRD by categories of eGFR and ACRa

ParametereGFR (ml/min per 1.73 m2)
≥6045 to 5930 to 4415 to 29
Normal ACR
    unadjusted1.0b30.8 (9.3 to 102.2)b76.0 (18.5 to 313.2)b583.1 (120.5 to 2822.0)c
    adjusted1.0b23.4 (6.7 to 82.1)b51.9 (11.5 to 233.5)b368.7 (69.2 to 1964.0)c
Microalbuminuria
    unadjusted33.9 (11.2 to 102.6)b227.4 (72.8 to 710.2)c740.6 (246.7 to 2222.0)c3833.0 (1265.0 to 11,611.0)d
    adjusted27.3 (8.8 to 84.5)b146.5 (42.7 to 502.7)c448.9 (133.7 to 1508.0)c2202.0 (632.5 to 7669.0)d
Macroalbuminuria
    unadjusted306.6 (50.3 to 1871.0)c1108.0 (285.8 to 4297.0)c3167.0 (1066.0 to 9403.0)d6957.0 (2286.0 to 21,165.0)d
    adjusted196.3 (27.6 to 1397.0)c641.1 (143.6 to 2862.0)c2036.0 (594.3 to 6973.0)d4146.0 (1187.0 to 14,482.0)d
  • a Numbers are unadjusted HR (95% CI) and HR after adjustment for age, gender, systolic BP, antihypertensive medication, diabetes, HDL cholesterol, and physical activity in a Cox regression analysis. Microalbuminuria was ACR ranging from 20 to 200 mg/g in men and 30 to 300 mg/g in women.

  • b Low risk for progression to ESRD.

  • c Medium risk for progression to ESRD.

  • d High risk for progression to ESRD.