Table 3.

Laboratory investigations for 66 patients assessed at stages 1 through 3 CKDa

ParameterMutation StatusP
HNF1B mut+HNF1B mut
MedianRangeMedianRange
Plasma magnesium (mg/dl [mM])1.68 (0.69)1.16 to 2.09 (0.48 to 0.86)2.02 (0.83)1.46 to 2.34 (0.60 to 0.96)<0.0001
Plasma calcium (mg/dl [mM])9.64 (2.41)8.84 to 10.40 (2.21 to 2.60)9.56 (2.39)8.16 to 10.88 (2.04 to 2.72)0.7500
Plasma phosphate (mg/dl [mM])4.24 (1.37)2.97 to 6.69 (0.96 to 2.16)4.57 (1.48)2.72 to 7.06 (0.88 to 2.28)0.3500
Blood albumin (g/dl)4235 to 494124 to 480.2600
Plasma PTH (ng/L [pM])59.40 (6.30)22.60 to 101.80 (2.40 to 10.80)46.63 (4.95)9.40 to 179.10 (1.00 to 19.00)0.2000
GFR (ml/min per 1.73 m2)73.032.0 to 113.070.530.0 to 123.00.8500
  • a Median plasma concentrations of magnesium and corresponding time-matched GFR, calcium, phosphate, albumin, and PTH values. n = 18 for mut+ and n = 48 for mut−, apart from PTH values, for which only a subset of values was available (mut+ n = 11; mutn = 35). Only plasma magnesium was significantly different among groups.